For Optimal Mental Performance
CILTEP® is a unique formula aimed at achieving your maximum potential by enhancing the brain’s innate mechanism for learning and memory. CILTEP works by chemically inducing long-term potentiation (LTP) using safe and all-natural chemical extracts. Scientists have known since the 1960s that synaptic plasticity and LTP is the intracellular mechanism used by neurones to encode memories in the brain. By naturally inducing LTP you will enhance your cognitive function and gain many benefits including:
CILTEP is formulated on the basis of artichoke and Coleus forskohlii extracts, which work synergistically to increase levels of the second messenger cyclic AMP in neural cells. These all-natural phytochemicals are a safe way of ensuring you are realizing your full cognitive potential.
Have you ever admired people who appear to be able to do anything they set their minds to? Who have total mental focus on their goals, can quickly master a new field of knowledge and remember everything they have learned? The idea that you can be like that by taking some pills sounds too good to be true at first glance. However, the brain is just a biochemical and cellular system, like any other organ in the body. It needs the right nutrients and biochemical to function at its optimal capacity. This is where smart drugs come in.
CILTEP is a nootropic supplement like no other, since it works by inducing long-term potentiation (LTP). LTP is the cellular mechanism by which brain neurons store long-term memories. Although much is still unknown about how LTP works, the one biochemical that scientists know is central to the process is cyclic AMP (cAMP,) and its target protein CREB. It is clear that increasing the levels of cAMP in neurons can induce LTP and allow the brain to work at its full potential.
CILTEP Artichoke Extract for PDE4 Inhibition
There are two ways in which cAMP levels can be increased, and CILTEP combines them both for maximum effect. The first way is inhibit the enzyme PDE4, which breaks down cAMP. A number of PDE4 inhibitors are being investigated by clinicians for their roles in improving learning, memory, and concentration. They were also shown to have neuro-protective and neuro-regenerative properties in preclinical studies. They are also candidates for novel antidepressants because of their mood stabilizing properties. However, synthetic PDE4 inhibitors have unpleasant side effects. CILTEP gets around this problem by using artichoke extract, which is a rich source of the bioactive phytochemical luteolin, a natural PDE4 inhibitor. Luteolin from artichoke extract gives you all the benefits of inducing TLP through increasing cAMP levels, without the side effects of artificial chemicals. CLITEP contains 900 mg of premium quality artichoke extract per capsule.
Foreskolin in CILTEP Stimulates cAMP Synthesis
The other method of increasing cAMP intracellular concentrations is to increase its synthesis. Foreskolin from the extract of the roots of the plant Coleus forskohlii, is an activator of the enzyme adenylyl cyclase that is needed for the production of cAMP. The increase in the intracellular cAMP levels after foreskolin treatment is well documented.
Each capsule of CLITEP contains 4 mg of foreskolin.
The two phytochemicals from natural extracts in CILTEP therefore work synergistically to increase the levels of cAMP in brain neurons by increasing cAMP production, and by inhibiting its breakdown.
Maintaining Optimal Neurotransmitter Levels
The CILTEP formula also includes L-phenylalanine and L-acetyl carnitine to maintain the optimal levels of the neurotransmitters dopamine and acetylcholine. Studies have shown that elevated levels of cAMP increase the activation of its target protein CREB, which in turn increase the expression of the gene for tyrosine hydroxylase. Tyrosine hydroxylase is the enzyme involved in the neurotransmitter dopamine metabolism. L-phenylalanine is a naturally occurring amino acid, and is a precursor of dopamine. Since dopamine increases wakefulness and alertness, increasing its levels is a desirable side effect. The supplementation with L-phenylalanine makes certain that the levels of the available amino acid do not limit the rate of its synthesis. It is important to remember that CILTEP elevates dopamine levels by acting through its normal metabolism, so there are none of the negative side effects that can be associated with dopamine stimulation with chemicals such as Adderall or Ritalin.
Scientists have demonstrated that one of the consequences of elevated intracellular cAMP levels, is an increase in the amount of acetylcholinesterase in neurons. Acetylcholinesterase is the enzyme that breaks down the neurotransmitter acetylcholine. This could be a negative side effect of forskolin supplementation, since high levels of acetylcholine are important for optimal brain function, learning and memory. The solution is to add ALCAR (acetyl L-Carnitine), the acetylated form of the amino acid carnitine. ALCAR inhibits the action of acetylcholinesterase. With the addition of ALCAR, the levels of acetylcholine are unaffected by forskolin, with no negative side effects on energy levels or short-term memory.
Vitamin B6 is an essential vitamin belonging to the B-complex. It is a cofactor necessary for the function of many enzymes, including those in the synthesis of neurotransmitters, such as dopamine, GABA, serotonin, and others. Vitamin B6 is added to the CILTEP stack since it is a cofactor of the enzyme DOPA carboxylase, which catalyzes the formation of dopamine from L-DOPA. Since one of the positive side effects of the elevation of cAMP is increased capacity to synthesise dopamine, additional B6 is added to ensure that optimal levels of the neurotransmitter can be synthesized.
Natural Stacks use only premium quality ingredients in formulating CILTEP, and the nootropic is synthesized in GMP facility. The formula is standardized so that the artichoke extract contains 5% total luteolin, and the Coleus forskohlii root extract is 20% foreskolin. For optimal results take 2-3 capsules in the morning on an empty stomach. Do not exceed 3 capsules. You could choose to take CILTEP 5 days a week, while having 2 days without supplementation.
The amazingly effective formulation of CILTEP depends on the dual action of natural phytochemicals in artichoke and Coleus forskohlii extracts. These bioactive plant chemicals activate enzymes that synthesise cAMP while inhibiting the PDE4 enzyme that breaks it down. This is an all-natural way to chemically induce long-term potentiation, the brain’s biochemical mechanism for storing memories. The result is safe but very effective nootropic stack, which enhances your cognitive abilities, long-term memory, concentration, and mental focus.
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