XBrain’s HMB supplement is especially designed for athletes and bodybuilders to increase strength and muscle gain. HMB is short for hydroxyl beta methyl butyrate, an all-natural substance produced in the body by the breakdown of the essential branched chain amino acid leucine. Clinical studies show that supplementing with extra HMB can increase lean muscle and strength when combined with an exercise regime. Researchers propose that HMB blocks protein breakdown and increases protein synthesis through three different mechanisms, which add up to produce up to an 18% increase in results.
HMB has both anabolic and anti-catabolic functions. On the one hand it promotes protein synthesis, which you need to build up lean muscle mass. On the other hand it blocks the degradation of muscle protein. Because a lot of its effects are very similar to the parent compound, leucine, some people think that some of the effects of leucine are in fact due to HMB.
HMB for Muscle Health
HMB is converted in the body to HMG-CoA, a molecule that is important for sarcolemmal integrity. The sarcolemma is a specialised cell membrane found around muscle fibres. By protecting this membrane HMB can decrease damage to muscle fibres and speed up the recovery period. Scientific studies also show that HMB decreases markers of muscle damage after exercise.
HMB Promotes an Anabolic State and Protein Synthesis
Scientists now think that HMB can improve muscle gain and prevent muscle loss through three different pathways. The first of these is to stimulate protein synthesis by signalling through the mTOR pathway, just the way leucine does. What HMB is doing in effect is to tell cells that there are a lot of nutrients available so they can go ahead, make a lot of new proteins and lay down new muscle fibres.
Prevent Protein Breakdown
It is also thought that HMB directly inhibits protein degradation through a pathway known as ubiquitination. In this pathway a small molecule called ubiquitin (because it is found in all cell types) is linked to protein molecules. This targets them for degradation in proteasomes. Obviously if you are a body builder or an athlete you don’t want your proteins to be degraded. HMB inhibits protein ubiquitination, and therefore has anti-catabolic activity.
These three very different mechanisms can add up to a whopping 18% increase in performance and muscle gain as discovered by scientists in clinical studies.
Scientists have known for a long time that the BCAA amino acid can inhibit protein degradation, among its other important benefits for muscle gain. However the does of leucine required for this anti-catabolic effect was much higher than for its anabolic effects. The dose was in fact much higher than that found in BCAA supplements. It is now thought that this anti-catabolic effect is due to HMB.
If you are already taking a BCAA supplement you might question whether you also need to buy HMB. The answer is yes. Although leucine, one of the branched chain amino acids is the parent coupound, only a small fraction, around 5% is degraded to HMB. The vast majority of leucine gives rise isovaleryl-CoA. It is estimated that you would need to consume 60g of leucine to get 3g of HMB. Obviously that is not practical, and you need to take an HMB supplement directly to obtain the anti-catabolic effects.
The high quality HMB supplement from XBrain will give you a lot of the anabolic effects of leucine in BCAA supplements, but will also add the inhibition of protein degradation, which you don’t get from the doses of leucine found in branched chain amino acid supplements. The synergistic action of anabolic and anti-catabolic effects, as well as the protection of muscle fibre sarcolemmal integrity adds up to a very significant increase in muscle gain. The HMB supplement will ensure that you gain maximum benefits from your training in terms of gaining lean muscle mass.
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